abstract：:Kindling represents an accepted model of human epileptogenesis. Furthermore, it has been demonstrated that kindled rats show a diminished learning performance in an active avoidance task. In our study we administered different nootropic drugs to kindled rats to test their effects on learning a two-way active avoidance...

journal_title：Pharmacological research

authors： Becker A,Grecksch G

更新日期：1995-09-01 00:00:00

abstract：:The accident to the nuclear power plant of Chernobyl (in April 1986) caused a radioactive contamination in large areas of the majority of European countries. During the first transient time the fall-out phenomenon was the most important method of contamination, particularly from 131I whose relative isotopic abundance ...

journal_title：Pharmacological research

authors： Curini M,Rosati O,Borio R,Saetta DM,Cicioni R,Forini N,Rongoni A,Dipilato AC

更新日期：1995-07-01 00:00:00

abstract：:In the present study the effect of ketamine, a dissociative anaesthetic, on the GABA- and on the specific GABAA-agonist muscimol-induced responses of the isolated guinea pig ileum was investigated. GABA as well as muscimol produce a concentration-dependent contractile effect on the duodenum, jejunum and ileum. The sen...

journal_title：Pharmacological research

authors： Kounenis G,Koutsoviti-Papadopoulou M,Elezoglou V

更新日期：1995-06-01 00:00:00

abstract：:It has demonstrated that carteolol can increase the endothelium-dependent vasodilation induced by alpha-2 adrenergic agonist. In order to evaluate the effect of carteolol, and to clarify the mechanism, we examined the effects of 10 microM carteolol on the vasodilation induced by increasing doses (10(-7)-10(-4) M) of c...

journal_title：Pharmacological research

authors： Ito M,Fukuda N,Izumi Y,Watanabe Y,Watanabe M,Soma M,Kanmatsuse K

更新日期：1995-05-01 00:00:00

abstract：:Tablets containing the inclusion complex of ursodeoxycholic acid (UDCA) with 2-hydroxypropyl-beta-cyclodextrin were prepared by direct compression. Plasma concentrations of UDCA were determined in six healthy volunteers after oral administration of tablets containing the inclusion complex or UDCA alone (Ursacol). Foll...

journal_title：Pharmacological research

authors： Panini R,Vandelli MA,Forni F,Pradelli JM,Salvioli G

更新日期：1995-03-01 00:00:00

abstract：:Levosulpiride is the (-)-enantiomer of sulpiride. It has shown greater central antidopaminergic activity, antiemetic and antidyspeptic effects and lower acute toxicity than both the racemic and dextro forms. Several clinical studies indicate that levosulpiride has therapeutic efficacy in depressive and somatoform diso...

journal_title：Pharmacological research

authors： Mucci A,Nolfe G,Maj M

更新日期：1995-02-01 00:00:00

abstract：:Plasma lipid and lipoprotein levels were evaluated in 27 adults with essential hypertension at four different periods during a 12-month treatment with doxazosin. Mean plasma total cholesterol (TC), low-density lipoprotein-cholesterol (LDLC), triglyceride (TG), very low density lipoprotein-cholesterol (VLDLC) and the L...

journal_title：Pharmacological research

authors： Ahaneku JE,Taylor GO,Agbedana EO,Walker O,Salako LA

更新日期：1994-10-01 00:00:00

abstract：:In the present study the effect of ketamine on the contractions caused by propoxur and phoxim on the isolated guinea pig ileum was investigated. Ketamine was found able to inhibit in a concentration-dependent manner the contractile responses of the ileum to propoxur and phoxim, while it did not significantly modify th...

journal_title：Pharmacological research

authors： Koutsoviti-Papadopoulou M,Kounenis G,Elezoglou V

更新日期：1994-08-01 00:00:00

abstract：:In the present study, an attempt has been made to elucidate the role of alpha 2-adrenoceptors in reserpine-induced emesis in pigeons. Reserpine was found to induce dose-dependent emesis and a 500 micrograms kg-1 dose was found to be the 100% emetic dose. alpha 2-adrenoceptor agonists clonidine and alpha-methylnoradren...

journal_title：Pharmacological research

authors： Khandker SK,Mukerjee D,Gurtu S,Pant KK,Dhawan KN,Sinha JN

更新日期：1994-05-01 00:00:00

abstract：:Results presented in this study demonstrate an association between the L-Histidine-mediated enhancement of H2O2-induced cytotoxicity and the formation of DNA double strand breakage (DSB), whereas no relationship exists between the increased cytotoxic response and DNA single strand breakage (SSB). Indeed, the higher le...

journal_title：Pharmacological research

authors： Cantoni O,Guidarelli A,Sestili P,Giacomoni PU,Cattabeni F

更新日期：1994-02-01 00:00:00

abstract：:Boldo (Peumus boldus Mol.), a Chilean tree traditionally employed in folk medicine and recognized as a herbal remedy in a number of pharmacopoeias, mainly for the treatment of liver ailments, has recently been the subject of increasing attention. Boldine, in particular, the major and most characteristic alkaloidal con...

journal_title：Pharmacological research

authors： Speisky H,Cassels BK

更新日期：1994-01-01 00:00:00

abstract：:A new class of methylfuroxans and methylfurazans arylthio, arylsulphinyl and arylsulphonyl substituted, characterized by vasodilating and antiaggregatory properties, is described. Vasodilating activity, tested on rabbit aortic rings percontracted with 1 microM noradrenaline, is enhanced by N-oxidation of the furazan r...

journal_title：Pharmacological research

authors： Ferioli R,Fazzini A,Folco GC,Fruttero R,Calvino R,Gasco A,Bongrani S,Civelli M

更新日期：1993-10-01 00:00:00

abstract：:The cytoprotective activity of alpha-lipoic acid against free radical toxicity, manifested during experimental hyperoxaluria, has been investigated. Glycollate was used as the inducer of oxalate hyperoxaluria in rats. The increase in lipid peroxidation and superoxide dismutase (SOD) activity, associated with a decreas...

journal_title：Pharmacological research

authors： Sumathi R,Jayanthi S,Kalpanadevi V,Varalakshmi P

更新日期：1993-05-01 00:00:00

abstract：:The effect of dexamethasone on the ability of activated J774 macrophages to inhibit platelet aggregation was investigated. After 24h incubation with lipopolysaccharide and gamma-interferon, J774 cells generated large amounts of nitric oxide and inhibited platelet aggregation. Incubation of the cells with dexamethasone...

journal_title：Pharmacological research

authors： Pinto A,Carnuccio R,Sorrentino R,Di Rosa M

更新日期：1993-02-01 00:00:00

abstract：:The gastrointestinal effects of single and repeated administration of ferrous sulphate was evaluated measuring faecal flora modifications and histology of stomach and duodenum of the rat. The acute experiments showed reversible histopathological lesions of stomach and duodenum with iron deposition and increase in faec...

journal_title：Pharmacological research

authors： Benoni G,Cuzzolin L,Zambreri D,Donini M,Del Soldato P,Caramazza I

更新日期：1993-01-01 00:00:00

abstract：:The effect of gentamicin on both glutamate synthesis and glutamate deamination was studied in kidney-cortex mitochondria and tubules isolated from both control and gentamicin-treated animals. In kidney-cortex mitochondria which were permeabilized in order to make a free access of substrates and antibiotic to the gluta...

journal_title：Pharmacological research

authors： Bryła J,Lietz T,Jarzyna R,Michalik M,Pietkiewicz J

更新日期：1992-12-01 00:00:00

abstract：:To assess the potential role of vasoactive cardiac eicosanoids in the modulation of coronary flow, we measure thromboxane(TX)B2, 6-keto-prostaglandin(PG)F1 alpha, PGE2 and sulphido-peptide leukotrienes (LTC4, D4, E4) in the coronary effluent of isolated perfused rat heart in both baseline and post-ischaemic conditions...

journal_title：Pharmacological research

authors： Giannessi D,Lazzerini G,Sicari R,DeCaterina R

更新日期：1992-12-01 00:00:00

abstract：:The antiepileptic drug vigabatrin (GVG) is known to decrease significantly the serum concentration of concurrently administered phenytoin (PHT) in epileptic patients. To assess a possible mechanism for this interaction, the effect of GVG on the intestinal absorption of PHT was investigated by means of circulation expe...

journal_title：Pharmacological research

authors： Tonini M,Gatti G,Manzo L,Olibet G,Coccini T,Perucca E

更新日期：1992-09-01 00:00:00

abstract：:In hypothermic rats with acute hypertension induced by intravenous injection of adrenalin, regional changes in blood-brain barrier permeability to macromolecules were investigated using Evans blue as indication. Evans blue albumin extravasation was determined as a macroscopic finding and a quantitative estimation with...

journal_title：Pharmacological research

authors： Oztaş B,Kaya M,Camurcu S

更新日期：1992-07-01 00:00:00

abstract：:The antitumour and immunosuppressive activities of spermine dialdehyde (SDA), a synthetic, oxidized form of spermine, were examined using L1210 cell lines and murine bone marrow cells. SDA acted as a high affinity substrate for aldehyde dehydrogenase (ADH) derived from different sources, with kinetic profiles similar ...

journal_title：Pharmacological research

authors： Kazmi SM,Li D,Koop K,Conant J,Lau CY

更新日期：1992-05-01 00:00:00

abstract：:Boron analogues of phosphonoacetates proved to be potent hypolipidaemic agents in rodents, lowering both serum cholesterol and triglyceride levels. (C2H5O)3PBH2COOCH3 proved to be the most effective agent in mice, lowering serum cholesterol 46% and serum triglycerides 54% after 16 days. (C2H5O)3PBH2COOH and Na+H+(C2H5...

journal_title：Pharmacological research

authors： Hall IH,Wong OT,Sood A,Sood CK,Spielvogel BF,Shrewsbury RP,Morse KW

更新日期：1992-04-01 00:00:00

abstract：:Steroids (aldosterone and testosterone) and peptides of cerebral origin (angiotensin II and the tachykinins) control the salt intake of the rat. They arouse or suppress the behaviour and produce life-long enhancements of NaCl intake. Need-induced salt intake (salt appetite or salt hunger), which is the consequence of ...

journal_title：Pharmacological research

authors： Epstein AN

更新日期：1992-02-01 00:00:00

abstract：:The anti-inflammatory effect of glucocorticoids depends, at least in part, on the induction of two regulatory proteins, lipocortin and vasocortin, both preventing the release of inflammatory mediators. Lipocortin inhibits phospholipase A2 (PLA2) and therefore reduces arachidonic acid metabolites formation. Vasocortin ...

journal_title：Pharmacological research

authors： Sautebin L,Carnuccio R,Ialenti A,Di Rosa M

更新日期：1992-01-01 00:00:00

abstract：:Electrophysiological effects of bisaramil--a new antiarrhythmic drug under clinical trial--were investigated on isolated heart preparations, at a concentration range of 2.3-23 x 10(-6) M. Bisaramil dose dependently decreased the maximum rate of depolarization (Vmax), action potential amplitude (APA) and overshoot (OS)...

journal_title：Pharmacological research

authors： Paroczai M,Karpati E,Marko R,Kecskemeti V

更新日期：1992-01-01 00:00:00

abstract：:In the present study we evaluated the protective activity of pyridoxol L,2-pyrrolidon-5 carboxylate (metadoxine) against CCl4 intoxication in rats, especially in relation to liver fibrosis. After 6 consecutive weeks of CCl4 treatment, the animals developed liver fibrosis and inflammation as revealed by histological an...

journal_title：Pharmacological research

authors： Annoni G,Contu L,Tronci MA,Caputo A,Arosio B

更新日期：1992-01-01 00:00:00

abstract：:The antioxidant properties of a novel water-soluble antioxidant of the benzofuran family (5-hydroxy-4,6,7-trimethyl-2,3-dihydrobenzofuran-2-acetic acid, BFA) were studied. In rat liver mitochondria BFA increases the lag-time and decreases the extent of lipid peroxidation induced by ascorbate/Fe2+; an IC50 value of abo...

journal_title：Pharmacological research

authors： Bindoli A,Rigobello MP,Musacchio E,Scuri R,Rizzoli V,Galzigna L

更新日期：1991-12-01 00:00:00

abstract：:The aim of this study is to investigate the acute haemodynamic effect of orally administered nisoldipine. Eight patients with stable angina and normal overall ventricular function were submitted to cardiac catheterization and angiography before and one hour after administration of nisoldipine 20 mg per os. Cardiac out...

journal_title：Pharmacological research

authors： Razzolini R,Boffa GM,Calvanese A,Isabella G,Ramondo A,Chioin R

更新日期：1991-10-01 00:00:00

abstract：:A simple method for solubilization and reconstitution of the A1 adenosine receptor from bovine brain is presented. Solubilization with CHAPS-phosphatidylcholine (CHAPS/PC) mixture did not alter the binding properties of the A1 adenosine receptor antagonist [3H]-DPCPX. The solubilized receptors were chromatographed on ...

journal_title：Pharmacological research

authors： Ragazzi E,Shryock J,Palczewski K

更新日期：1991-07-01 00:00:00

abstract：:Cytochrome P450-dependent arachidonic acid (AA) metabolism by medullary thick ascending limb of the loop of Henle (mTALH) cells, corneal epithelium and other transporting epithelia, such as those of the intestines, generate metabolites which affect Na(+)-K(+)-ATPase activity, vasomotion and, thereby, organ function. F...

journal_title：Pharmacological research

authors： Carroll MA,Quilley CP,McGiff JC

更新日期：1991-05-01 00:00:00

abstract：:In this investigation we have examined the effects of indomethacin, an inhibitor of the cyclooxygenase pathway of arachidonic acid, upon the kinetics of the release of tumour necrosis factor alpha (TNF) and of the expression of TNF gene by lipopolysaccharide (LPS)-stimulated human blood monocytes (BM). Following stimu...

journal_title：Pharmacological research

authors： Spatafora M,Chiappara G,D'Amico D,Volpes D,Melis M,Pace E,Merendino A

更新日期：1991-04-01 00:00:00

abstract：:Beta-endorphin/beta-lipotropin immunoreactivity (BE/BLPH-IR) content was evaluated in the CSF of patients suffering by deafferentation pain syndromes. BE/BLPH-IR CSF concentrations of these patients were compared with those obtained in a group of patients affected by low back pain and in a control group without pain p...

journal_title：Pharmacological research

authors： Salar G,Alessio L,Govoni S,Battaini F,Iob I,Goss I,Trabucchi M

更新日期：1991-02-01 00:00:00

abstract：:Many data suggest an involvement of toxic oxygen radicals in the termination of endurance to muscle fatigue. Being reduced glutathione (GSH), an efficient intracellular physiological antioxidant, experiments have been performed to discover whether exogenous GSH modifies endurance to exhaustive swimming in mice. GSH wa...

journal_title：Pharmacological research

authors： Novelli GP,Falsini S,Bracciotti G

更新日期：1991-02-01 00:00:00

abstract：:As a function of the structural modification of the steroid nucleus, the inhibitory interaction of 11 progesterone derivatives with human Na/K-ATPase (Na+/K(+)-transporting ATPase, EC 3.6.1.37), through C3-O-rhamnosylation, is either much decreased or weakly up to strongly increased, so that the rhamnosyl residue cont...

journal_title：Pharmacological research

authors： Weiland J,Schönfeld W,Menke KH,Repke KR

更新日期：1991-01-01 00:00:00

abstract：:In previous studies we observed an enhanced anti-inflammatory activity of MPEG-SOD derivatives in acute inflammation in rat. To assess the activity in chronic inflammation we tested the compound with longer half-life (MPEG-SOD 18) in complete adjuvant arthritis in rat. According to the prophylactic schedule of treatme...

journal_title：Pharmacological research

authors： Conforti A,Caliceti P,Sartore L,Schiavon O,Veronese F,Velo GP

更新日期：1991-01-01 00:00:00

abstract：:In the isolated myometrium obtained from pregnant women, diphenylhydantoin inhibited both spontaneous and K(+)-evoked contractions within the same range of potency. Nicardipine was less effective in inhibiting spontaneous than K(+)-induced contractions, whereas trifluoperazine was only effective against spontaneous co...

journal_title：Pharmacological research

authors： Medeiros YS,Calixto JB

更新日期：1990-09-01 00:00:00

abstract：:The EEG and behavioural changes induced by the administration of polyamines (spermine and spermidine) were studied in rabbit. Spermine and spermidine were administered at different doses (200 and 400 micrograms) into the mesencephalic ventricle (i.c.v.) both as a bolus and in constant perfusion (60 min duration). We a...

journal_title：Pharmacological research

authors： Bo P,Giorgetti A,Camana C,Savoldi F

更新日期：1990-07-01 00:00:00

abstract：:By the use of combined radioreceptor binding and autoradiographic techniques we attempted to analyse the biochemical characteristics and the anatomical localization of GABA-B receptors in sections of rat circle of Willis and pialarachnoid arteries. 3H-GABA in the presence of 40 microM isoguvacine and 2.5 mM CaCl2 was ...

journal_title：Pharmacological research

authors： Napoleone P,Ferrante F,Amenta F

更新日期：1990-05-01 00:00:00

abstract：:The modification in the composition of bile acids in hamster by the administration of high dose of ursodeoxycholic acid (UDCA) was investigated. Male Golden Syrian hamsters were divided into five groups: a control group, two groups that received 0.5 g of UDCA per 100 g of standard diet during 30 and 60 days and anothe...

journal_title：Pharmacological research

authors： Matejka M,Vescina C,Carducci CN,Alayón A,Dios A,Scarlatto E,Mamianetti A

更新日期：1990-05-01 00:00:00

abstract：:Cytophotometric measurement of the effect of praziquantel (500 mg/kg for 2 days) versus hycanthone (60 mg/kg for 3 days) on hepatocyte nuclear deoxyribonucleic acid (DNA) content was evaluated in Schistosoma mansoni infected mice. Drugs were given 8 weeks post-infection and repeated weekly for 4 weeks. DNA values of i...

journal_title：Pharmacological research

authors： Botros SS

更新日期：1990-03-01 00:00:00

abstract：:Antidepressants, especially tricyclic agents (TCAs), are increasingly used in geriatric patients since depression is a common mood disorder in the elderly and the size of elderly population is increasing. Notwithstanding the importance of kinetics to better use of drugs, its study in the elderly (regarding TCAs) is no...

journal_title：Pharmacological research

authors： Furlanut M,Benetello P

更新日期：1990-01-01 00:00:00